Keep track of Carefully (2)pentobarbital will lessen the level or influence of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Powerful CYP3A4 inducers may possibly minimize suvorexant efficacy; if improved suvorexant dose needed, don't exceed 20 mg/working dayDrugs which have step therapy involved with J